- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Chapter 111 Examining the nervous system of an older patient
- Chapter 112 Peripheral neuropathies and motor neuron disorders
- Chapter 113 Headaches and facial pain
- Chapter 114 Traumatic brain injury and subdural haematoma
- Chapter 115 Seizure disorders and management
- Chapter 116 Parkinsonism, Parkinson’s disease, and related conditions
- Chapter 117 Stroke: epidemiology of different types of strokes
- Chapter 118 Primary and secondary prevention of stroke
- Chapter 119 Management of acute stroke within the stroke pathway and stroke clinics
- Chapter 120 Neurological rehabilitation
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
(p. 871) Peripheral neuropathies and motor neuron disorders
- Chapter:
- (p. 871) Peripheral neuropathies and motor neuron disorders
- Author(s):
Stéphane Mathis
and Jean-Michel Vallat
- DOI:
- 10.1093/med/9780198701590.003.0112_update_001
Update:
For diabetic neuropathy, we added further details about its prognostic.
Some information about nodo-paranodopathies (acute and chronic) were provided.
We highlighted the difficulties for classifying Charcot-Marie-Tooth, due to the too many implicated genes (nowadays more than 10 genes were found).
For amyotrophic lateral sclerosis, we added a sentence about edaravone, an antioxidant treatment now used in addition to riluzole.
Peripheral nervous system disorders are common in older people. Most peripheral neuropathies are secondary to metabolic (diabetes) or toxic causes (medications, alcohol), but several other aetiologies are possible, requiring clinical, electrophysiological, biological, and sometimes pathological (nerve biopsy) examinations to make the right diagnosis and instigate effective treatments. However, despite using this strategy, no cause is found in some axonal polyneuropathies, leading to the concept of chronic idiopathic axonal polyneuropathy (CIAP). Amyotrophic lateral sclerosis (ALS) affects the peripheral nervous system, but is also characterized by central nervous system involvement: it is a strictly motor disorder affecting both the first and second motor neurons, usually presenting during the sixth or seventh decade. This rapidly progressive, still incurable neurodegenerative disease leads to death in all cases.
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- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Chapter 111 Examining the nervous system of an older patient
- Chapter 112 Peripheral neuropathies and motor neuron disorders
- Chapter 113 Headaches and facial pain
- Chapter 114 Traumatic brain injury and subdural haematoma
- Chapter 115 Seizure disorders and management
- Chapter 116 Parkinsonism, Parkinson’s disease, and related conditions
- Chapter 117 Stroke: epidemiology of different types of strokes
- Chapter 118 Primary and secondary prevention of stroke
- Chapter 119 Management of acute stroke within the stroke pathway and stroke clinics
- Chapter 120 Neurological rehabilitation
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing