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Haematology 

Haematology
Chapter:
Haematology
Author(s):

Heather Baid

, Fiona Creed

, and Jessica Hargreaves

DOI:
10.1093/med/9780198701071.003.0014
Page of

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date: 21 September 2019

The pathophysiology, management, and treatment of erythrocyte disorders, such as polycythaemia and sickle-cell anaemia, and leucocyte disorders, such as neutropenia and the various types of leukaemia, are explained. The causes and management of thrombocyte disorders, including thrombocytopenia, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, and heparin-induced thrombocytopenia syndrome are also described. There is a review of the pharmacology, indications, monitoring, and reversal procedures for a range of medications that are used for anticoagulant therapy, including heparin, warfarin, factor Xa inhibitors, clopidogrel, thrombolytic agents, and direct thrombin inhibitors. Specific clotting disorders are considered, including disseminated intravascular coagulation and haemophilia. The final section focuses on the transfusion of blood components, including packed red blood cells, platelets, fresh frozen plasma, and cryoprecipitate. The complications and hazards of transfusion are also summarized.

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