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Heather Baid

, Fiona Creed

, and Jessica Hargreaves

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date: 21 September 2019

The chapter begins with an introduction to the spectrum of terminology related to sepsis, and differentiates between systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, sepsis-induced hyotension, and sepsis-induced tissue hypoperfusion. The clinical presentation of sepsis and severe sepsis is then described with reference to the Surviving Sepsis Campaign guidelines, and the causes and risk factors for neutropenic sepsis are discussed. The role of the Sepsis 6 interventions in improving patient outcome is considered, and the concept of early goal-directed therapy is described. Two different care bundles for patients with sepsis are presented, and the management of severe sepsis, including initial resuscitation and infection issues, haemodynamic support, and other forms of supportive therapy is described.

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