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Neurobiology and the genetics of suicide 

Neurobiology and the genetics of suicide
Neurobiology and the genetics of suicide

Danuta Wasserman

, Sokolowski Marcus

, Jerzy Wasserman

, and Dan Rujescu

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date: 27 January 2022

Besides serotonin dysfunction, which was the main focus for about three decades, many other aspects of brain neurobiology have now been shown to be involved in the causality of suicidal behaviour. This chapter attempts to provide a broad overview of the entire range of studies performed in the area of neurobiology of suicide. The investigated involvement of genetics in each presently known neurobiological alteration is likewise presented. Although, the complexities and challenges in this field may sometimes seem overwhelming, this overview shows that the knowledge in this area is constantly being increased and refined in its details, and small breakthroughs occur constantly. Thus, it appears that if sufficient time and resources are dedicated to this problem, a critical mass of understanding will be reached, enabling the development of entirely novel tools for prevention of suicide.

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