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Sites of MS attack and clinically isolated syndromes 

Sites of MS attack and clinically isolated syndromes
Sites of MS attack and clinically isolated syndromes

John Zajicek

, Jennifer Freeman

, and Bernadette Porter

Page of

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date: 11 August 2020

Typical presentations of clinically isolated syndromes 80

Differential diagnosis in MS and clinically isolated syndromes 88

Specific demyelinating syndromes 92

MS tends to present with specific syndromes, with a predilection to attack particular parts of the central nervous system, namely the optic nerves, the spinal cord and the brainstem. This is partly because these co-called eloquent areas contain a high density of important nerve pathways so that relatively small areas of inflammation may have significant clinical effects, which are readily noticed. However, they may also be other reasons to do with blood supply and expression of particular molecules that may play a role in the pathogenesis of MS....

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