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Infection 

Infection
Chapter:
Infection
DOI:
10.1093/med/9780197525227.003.0010
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date: 27 October 2021

The infection chapter captures all the clinical indicators of possible neonatal infection that appear as Alerting Signs (marked with an asterisk [*]) in almost every ACoRN Sequence. Infection signs require appropriate response and follow-up, but these and associated risk factors for infection are now evaluated as ‘higher risk’ (red flags) or ‘lower risk’ (non-red flags) in the Infection Assessment Table. Care and treatment of suspected infections, including early antibiotics while awaiting cultures, are determined by the presence and number of red flags and non-red flags. The presence of two or more non-red flags heightens risk for sepsis in the newborn, an often subtle condition which impacts stabilization across multiple systems. Diagnostic tests to determine infection site and causative organism are described and evaluated. Close observation and frequent reassessment of infant status using the ACoRN Primary Survey and Sequences are recommended. Two case scenarios compare respiratory distress risk for infection.

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