- Contributors
- 1 The 100th Anniversary of the Ketogenic Diet
- 2 Overview: Ketogenic Diets and Pediatric Epilepsy
- 3 Alternative Ketogenic Diets
- 4 Ketogenic Diet Therapies in Adults
- 5 How Do You Implement the Diet?
- 6 GLUT1 Deficiency Syndrome and the Ketogenic Dietary Therapies
- 7 Ketogenic Diet in Established Epilepsy Indications
- 8 Ketogenic Diet for Other Epilepsies
- 9 The Ketogenic Diets in Genetic Generalized Epilepsy Syndromes
- 10 Ketogenic Diet Therapy for Infants
- 11 Ketogenic Diet in Status Epilepticus
- 12 Preventing Side Effects and Diet Discontinuation
- 13 Overview
- 14 Metabolism-Based Treatments for Managing Cancer
- 15 Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer
- 16 Ketogenic Diet, Social Behavior, and Autism
- 17 Ketotherapeutics to Rescue Brain Energy Deficits
- 18 Ketogenic Diet and Ketones for Improving Neurologic Outcomes after Acute Neurotrauma
- 19 Ketogenic Diets and Neuroinflammation
- 20 The Ketogenic Diet in the Treatment of Schizophrenia
- 21 The Ketogenic Diet and the Gut Microbiome
- 22 Overview: Ketogenic Diet in the Laboratory
- 23 Ketogenic Diet and PPARγ
- 24 Ketogenic Diet and Adenosine in Epilepsy
- 25 Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis
- 26 Ketogenic Diet, Aging, and Neurodegeneration
- 27 Metabolic Seizure Resistance via BAD and KATP Channels
- 28 Lactate Dehydrogenase
- 29 Effects of the Ketogenic Diet on the Blood–Brain Barrier
- 30 Metabolic and Redox Alterations by Ketogenic Diets
- 31 Nicotinamide Adenine Dinucleotide as a Central Mediator of Ketogenic Therapy
- 32 Overview
- 33 Ketone Supplementation for Health and Disease
- 34 Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis
- 35 Amino Acids in the Treatment of Neurologic Disorders
- 36 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet
- 37 Triheptanoin in Epilepsy and Beyond
- 38 Antiseizure and Antiepileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose
- 39 Low-Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity
- 40 Intermittent Exogenous Ketosis for Athletic Performance, Recovery, and Adaptation
- 41 Advancing the Awareness and Application of Ketogenic Therapies Globally
- Index
(p. 423) Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis
- Chapter:
- (p. 423) Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis
- Author(s):
Zsolt Kovacs
, Dominic P. D’Agostino
, and Csilla Ari
- DOI:
- 10.1093/med/9780197501207.003.0034
Emerging evidence from numerous studies suggests that administration of exogenous ketone supplements, such as ketone salts and ketone esters, may have a therapeutic influence on several central nervous system disorders through neuroprotective and behavioral effects. Therefore, ketone supplementation is a potential therapeutic tool for epilepsy, neurodegenerative, and psychiatric disorders. Ketosis evoked by exogenous ketone supplements can exert its beneficial effects, for example, through modulation of mitochondrial function, hydroxycarboxylic acid receptor 2, histone deacetylases, and the NOD-like receptor pyrin domain 3 inflammasome. In this chapter, the ketone-induced metabolic and downstream signaling effects associated with mitigating treatment-resistant neurodegenerative and behavioral disorders are summarized and the rationale for the development and testing of specific ketone-based adjunctive treatments is outlined.
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- Contributors
- 1 The 100th Anniversary of the Ketogenic Diet
- 2 Overview: Ketogenic Diets and Pediatric Epilepsy
- 3 Alternative Ketogenic Diets
- 4 Ketogenic Diet Therapies in Adults
- 5 How Do You Implement the Diet?
- 6 GLUT1 Deficiency Syndrome and the Ketogenic Dietary Therapies
- 7 Ketogenic Diet in Established Epilepsy Indications
- 8 Ketogenic Diet for Other Epilepsies
- 9 The Ketogenic Diets in Genetic Generalized Epilepsy Syndromes
- 10 Ketogenic Diet Therapy for Infants
- 11 Ketogenic Diet in Status Epilepticus
- 12 Preventing Side Effects and Diet Discontinuation
- 13 Overview
- 14 Metabolism-Based Treatments for Managing Cancer
- 15 Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer
- 16 Ketogenic Diet, Social Behavior, and Autism
- 17 Ketotherapeutics to Rescue Brain Energy Deficits
- 18 Ketogenic Diet and Ketones for Improving Neurologic Outcomes after Acute Neurotrauma
- 19 Ketogenic Diets and Neuroinflammation
- 20 The Ketogenic Diet in the Treatment of Schizophrenia
- 21 The Ketogenic Diet and the Gut Microbiome
- 22 Overview: Ketogenic Diet in the Laboratory
- 23 Ketogenic Diet and PPARγ
- 24 Ketogenic Diet and Adenosine in Epilepsy
- 25 Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis
- 26 Ketogenic Diet, Aging, and Neurodegeneration
- 27 Metabolic Seizure Resistance via BAD and KATP Channels
- 28 Lactate Dehydrogenase
- 29 Effects of the Ketogenic Diet on the Blood–Brain Barrier
- 30 Metabolic and Redox Alterations by Ketogenic Diets
- 31 Nicotinamide Adenine Dinucleotide as a Central Mediator of Ketogenic Therapy
- 32 Overview
- 33 Ketone Supplementation for Health and Disease
- 34 Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-Evoked Ketosis
- 35 Amino Acids in the Treatment of Neurologic Disorders
- 36 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet
- 37 Triheptanoin in Epilepsy and Beyond
- 38 Antiseizure and Antiepileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose
- 39 Low-Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity
- 40 Intermittent Exogenous Ketosis for Athletic Performance, Recovery, and Adaptation
- 41 Advancing the Awareness and Application of Ketogenic Therapies Globally
- Index
