Show Summary Details
Page of

Animal Models 

Animal Models
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 26 May 2019

An animal model using the pigtailed macaque co-infected with two SIV viruses recapitulates key clinical and pathological features of HIV infection of the peripheral and central nervous system (PNS, CNS). The pigtailed macaques in this model develop immunosuppression more rapidly than similarly co-infected rhesus macaques, and develop CNS lesions more frequently than either rhesus macaques or cynomologous monkeys when similarly coinfected. In this pigtail model, the majority of animals develop AIDS as well as CNS and PNS disease by 84 days post inoculation. Furthermore, this model recapitulates the acute, asymptomatic, and late stages of infection and disease in the CNS, making it possible to study stage-specific longitudinal viral and immunological changes and responses to therapies. This chapter discusses a range of important topics relevant to understanding SIV models of AIDS and NeuroAIDS in general, as well as this pigtail model in particular. These topics include areas related to normal immune responses, genetic susceptibilities, pathogenesis of HIV disease, and preclinical testing of neuroprotective agents.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.