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Viral Clades: Role In Hiv Neuropathogenesis 

Viral Clades: Role In Hiv Neuropathogenesis
Chapter:
Viral Clades: Role In Hiv Neuropathogenesis
Author(s):

Wenxue Li

and Avindra Nath

DOI:
10.1093/med/9780195399349.003.0061
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date: 17 June 2019

Despite the rapid transglobal spread of HIV-1 infection, it has emerged as distinct subtypes or clades in different geographical regions. This sequence diversity seems to have profound effects in the spread of the virus, its ability to infect various cells types, the efficiency of viral replication, the propensity to develop drug resistance and their ability to cause neurocognitive disorders. While clade B virus is the still the best studied, it is becoming evident that clade D infected individuals have higher rates of neurocognitive disorders while the converse may be true for clade C infected individuals. This chapter reviews the evidence and the molecular basis for these clade differences.

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