Show Summary Details
Page of

Viral and Cellular Biomarkers During Antiretroviral Therapy 

Viral and Cellular Biomarkers During Antiretroviral Therapy
Chapter:
Viral and Cellular Biomarkers During Antiretroviral Therapy
Author(s):

Scott L. Letendre

and Ronald J. Ellis

DOI:
10.1093/med/9780195399349.003.0059
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 June 2019

The persistence of HIV-associated neurocognitive disorders (HAND) in patients who seem to be effectively treated with antiretroviral therapy is a subject of active investigation. This chapter examines the effects of antiretroviral therapy on viral and host biomarkers, drawing particular attention to data indicating that antiretroviral treatment may not be fully adequate with respect to the central nervous system. The chapter's focus is limited to biomarkers in cerebrospinal fluid, which is commonly used as a surrogate for pathologic and therapeutic events in the brain. In constructing this review, we performed a PubMed keyword search for “antiretroviral AND cerebrospinal fluid” and selected those publications that contained data relevant to the effects of antiretroviral therapy on a viral or host biomarker. Additional references were identified using marker-specific search terms such as “β2 microglobulin AND cerebrospinal fluid AND HIV.”

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.