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Viral and Cellular Biomarkers During Antiretroviral Therapy 

Viral and Cellular Biomarkers During Antiretroviral Therapy
Viral and Cellular Biomarkers During Antiretroviral Therapy

Scott L. Letendre

and Ronald J. Ellis

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date: 14 July 2020

The persistence of HIV-associated neurocognitive disorders (HAND) in patients who seem to be effectively treated with antiretroviral therapy is a subject of active investigation. This chapter examines the effects of antiretroviral therapy on viral and host biomarkers, drawing particular attention to data indicating that antiretroviral treatment may not be fully adequate with respect to the central nervous system. The chapter's focus is limited to biomarkers in cerebrospinal fluid, which is commonly used as a surrogate for pathologic and therapeutic events in the brain. In constructing this review, we performed a PubMed keyword search for “antiretroviral AND cerebrospinal fluid” and selected those publications that contained data relevant to the effects of antiretroviral therapy on a viral or host biomarker. Additional references were identified using marker-specific search terms such as “β2 microglobulin AND cerebrospinal fluid AND HIV.”

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