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Hepatitis C 

Hepatitis C
Chapter:
Hepatitis C
Author(s):

Li Ye

and Wenzhe Ho

DOI:
10.1093/med/9780195399349.003.0054
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date: 17 June 2019

Hepatitis C virus (HCV) affects over 170 million people world wide and four million people in the United States. It is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. It also causes a variety of extrahepatic syndromes, including cryoglobulinemia, glomerulonephritis, porphyria cutanea tarda, and neurological dysfunctions. Coinfection of HIV and HCV is very common among injection drug users. In patients with HIV infection, HCV coinfection accelerates HIV-disease progression and is an important source of increased HIV-associated morbidity and mortality. A combination of interferon-alpha (IFN-?) and ribavirin is currently the only available treatment for HCV infection. This treatment has a success rate of only about 50 percent and is often associated with serious side effects. This chapter focuses on the role of HCV infection in neurological dysfunction. Topics covered include: HCV infection in the CNS, HCV and neurological dysfunction, HCV and depression, mechanisms of HCV-associated cognitive impairment, effects of anti-HCV therapy on cognitive functioning, and the impact of HIV-HCV coinfection on cognitive functioning.

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