Show Summary Details
Page of

Progressive Multifocal Leukoencephalopathy 

Progressive Multifocal Leukoencephalopathy
Chapter:
Progressive Multifocal Leukoencephalopathy
Author(s):

Maria G. Chiara

and Eugene O. Major

DOI:
10.1093/med/9780195399349.003.0052
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 May 2019

Progressive multifocal leukoencephalopathy (PML), caused by the JC Virus (JCV), is a demyelinating disease of the white matter of the human brain. It is one of the principal opportunistic infections afflicting HIV-1-positive individuals and is an AIDS-defining illness. The role of the immune system in the pathogenesis of PML is complex. Interactions between the JC and HIV viruses further complicates the picture. Normally held in check by the immune system, JCV can become lethally active in AIDS patients either early in the progression of AIDS or in the months immediately following initiation of HAART in the form of immune reconstitution inflammatory syndrome (IRIS). This chapter provides an overview of many aspects of PML in AIDS, including reviews of the pathology, diagnosis, and incidence of PML, and of the association of PML with IRIS; a comparison of PML in AIDS vs. in other immunosuppressive disorders; a discussion of PML pathogenesis from viral latency through demyelination; and a discussion of PML in patients undergoing pharmacologic immunosuppression.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.