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CNS Comorbidities 

CNS Comorbidities
Chapter:
CNS Comorbidities
Author(s):

Georgette D. Kanmogne

and David B. Clifford

DOI:
10.1093/med/9780195399349.003.0050
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date: 23 May 2019

This chapter gives a structured overview of the major HIV-related opportunistic and non-opportunistic infections of the CNS, including discussion of their interactions with immune reconstitution inflammatory syndrome (IRIS), stressing their pathogenesis, how they are affected by combination antiretroviral therapy, and the influence of geographic setting on prevalence, morbidity, and mortality. Part I discusses opportunistic infections (OIs). Considered are cytomegalovirus, cryptococcus, toxoplasmosis, and progressive multifocal leukoencephalopathy. Part II discusses IRIS and its interactions with specific OIs. Part III considers non-opportunistic infectious CNS complications, especially primary CNS lymphoma (closely associated with Epstein-Barr virus) and HIV encephalopathy.

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