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Myopathy 

Myopathy
Chapter:
Myopathy
Author(s):

Jessica Robinson-Papp

, Kenneth A. Fox

, David M. Simpson

, and Susan Morgello

DOI:
10.1093/med/9780195399349.003.0044
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date: 26 May 2019

Skeletal muscle disorders associated with HIV infection are myriad. These disorders may present as initial symproms of HIV disease or at any time during the course of infection. Diagnosis is not always straightforward, as multiple pathologies may coexist in the same patient and myopathies may be masked by concomitant central nervous system disorders. Neuromuscular disorders may be caused by HIV infection itself or arise secondarily as a result of a variety of processes that are associated with HIV infection, including as a treatment side effect. Furthermore, the insidious progression of most neuromuscular disorders may be overlooked in the advanced stages of AIDS, when other complications dominate the clinical picture. Prompt recognition of neuromuscular disease is important in HIV-infected patients, as therapy may dramatically improve the patient's quality of life. This chapter reviews the spectrum of myopathies that occurs in association with HIV infection and treatment. We describe the clinical, electrophysiological, and pathological features of these disorders, and discuss theories of pathogenesis and options for management.

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