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Sulie L. Chang

and Marley D. Kass

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date: 07 July 2020

The development and optimization of animal models for neuroAIDS research is a challenging but necessary step toward delineating and effectively treating the central and peripheral neuropathologies that emerge with long-term HIV infection in humans. Because large-animal models, such as non-human primate models, are expensive and of limited availability, developing small-animal models of HIV disease, including with mice and rats, is important. Although certain aspects of HIV disease are modeled well by murine leukemia viruses and with the xenotransplantation of severe combined immunodeficient mice, there are situations where transgenic (Tg) models are uniquely valuable. Tg mice and rats expressing either the full HIV-1 genome or specific HIV-1 genes can mimic neuropathological abnormalities and cognitive, motor, and behavioral impairments observed in human HIV-1 disease. This chapter provides a detailed overview of transgenic murine models for HIV infection in humans.

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