Show Summary Details
Page of

Caprine Arthritis Encephalitis Virus and Visna 

Caprine Arthritis Encephalitis Virus and Visna
Chapter:
Caprine Arthritis Encephalitis Virus and Visna
Author(s):

Valgerdur Andrésdóttir

, Sigurbjörg Torsteinsdóttir

, and Gudmundur Georgsson

DOI:
10.1093/med/9780195399349.003.0027
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 June 2019

Maedi-visna virus and Caprine arthritis-encephalitis virus are lentiviruses that cause epizootics in, respectively, sheep and goats. These viruses do not cause overt immunosuppression but the immune responses they engender are ineffective at eradicating the infections. Both viruses can cause encephalitis and both share important features with SIV and HIV infections, especially pertaining to the initial steps in the development of central nervous system (CNS) lesions. The main target cells for productive infection in the brain are cells of the monocyte/macrophage lineage; and the mechanisms for virus entry into the CNS may be similar for all the lentiviruses. These viruses and their animal hosts are valuable models for aspects of HIV infection in humans, and are especially well suited for the study of AIDS neurology. This chapter describes these viruses and the pathogenic features they possess that are relevant to the modelling of human HIV infection.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.