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HIV-1 and Meth 

HIV-1 and Meth
Chapter:
HIV-1 and Meth
Author(s):

Howard S. Fox

DOI:
10.1093/med/9780195399349.003.0022
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date: 26 May 2019

The stimulant dextro (D)-Methamphetamine hydrochloride (methamphetamine, Meth) is a member of the amphetamine family of abused drugs. Meth is chemically related to amphetamine (dextroamphetamine), with the additional methyl group giving it enhanced lipophilicity, which increases its ability to cross the blood-brain barrier. Significant demographic overlap exists between those who use Meth and those at risk for HIV infection. Several research groups have studied the interaction of Meth and HIV in humans. HIV and Meth appear to have adverse, additive effects on frontal and striatal neuronal and glial markers; and rates of neurocognitive impairment appear to be higher in HIV-positive individuals who use Meth vs. those who do not. This chapter presents the result of clinical trials, non-human primate studies, and non-primate animal studies relevant to interactions between Meth use and HIV. The chapter also discusses Meth toxicity, the effects of Meth on central nervous system function, and interactions among aging, chronic HIV infection, and Meth use.

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