Show Summary Details
Page of

Neurogenesis 

Neurogenesis
Chapter:
Neurogenesis
Author(s):

James B. Reinecke

, Hui Peng

, Yunlong Huang

, Qiang Chen

, and Jialin C. Zheng

DOI:
10.1093/med/9780195399349.003.0011
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 June 2019

Neurogenesis is a highly regulated process responsible for the generation of new neurons, astrocytes and oligodendrocytes from neural stem cells. Previously, neurogenesis was thought to be a pre-natal phenomenon, halting shortly after birth. Intense investigation over the past decade and a half has reversed that theory. It is now widely accepted that neurogenesis persists into adulthood and may play a crucial role in complicated behaviors such as learning and memory. Consequently, accumulating evidence suggests that impaired neurogenesis may contribute to the pathogenesis of several brain disorders. The purpose of this chapter is three-fold. First, we will describe the process of developmental and adult neurogenesis. Furthermore, the relationship between brain disorders and neurogenesis will be extensively reviewed, with emphasis on how brain inflammation may influence the pathogenesis of neurodegenerative diseases such as HIV-1 associated neurocognitive disorders. Lastly, we will explore how new advances in stem cell biology may lead to exciting new therapies for the treatment of neurodegenerative disorders.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.