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Genetic Susceptibilities for NeuroAIDS 

Genetic Susceptibilities for NeuroAIDS
Chapter:
Genetic Susceptibilities for NeuroAIDS
Author(s):

Srinivas Mummidi

, Jason F. Okulicz

, Edwina J. Wright

, Weijing He

, and Sunil K. Ahuja

DOI:
10.1093/med/9780195399349.003.0005
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date: 17 June 2019

Among HIV-1 infected patients, clinical involvement of the central and peripheral nervous systems is widespread but far from universal, even among untreated patients. The precise basis for differences among individuals in the natural history of HIV-1 disease is largely unknown. Conceptually, these differences may be attributed to environmental, viral, host, and other factors. This chapter focuses specifically on host genetic polymorphisms that influence susceptibility to the spectrum of HIV-1 associated neurological disorders, peripheral neuropathies, and central nervous system (CNS) opportunistic infections. Particular attention is paid to polymorphisms for cytokines, chemokines and their receptors, and a number of other cellular products (Apolipoprotein E, Mannose Binding Lectin). Also discussed are polymorphic determinants of drug-related CNS effects (Efavirenz) and of progressive multifocal leukoencephalopthy and non-determined leukoencephalpathy.

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