Show Summary Details
Page of

Chemokines 

Chemokines
Chapter:
Chemokines
Author(s):

Richard J. Miller

DOI:
10.1093/med/9780195399349.003.0003
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 May 2019

HIV-1 related central and peripheral nervous system problems are highly prevalent but the details of their pathogenesis are poorly understood. A widely held hypothesis is that infected cells in the nervous system secrete neurotoxins that exert direct and indirect deleterious effects. Candidate neurotoxins include excitotoxins, inflammatory mediators, and HIV-1 viral proteins. There is evidence that chemokines and chemokine receptors, which are expressed in all major cell types in the brain, may play pivotal roles in many of these diverse neurotoxic processes. This chapter explores these possible roles. Close attention is paid to a several proposed mechanisms, including those involving the CXCR4 chemokine receptor and the HIV gp120 protein, whose effects may be partly mediated by cytokine-related processes. To help provide a framework for understanding these complex pathogenic phenomena, the roles of chemokines and chemokine receptors in normal development and function is discussed.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.