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Molecular Mechanisms Guiding B-Cell Development: Territorial Administration under Attack in Orleans and Washington 

Molecular Mechanisms Guiding B-Cell Development: Territorial Administration under Attack in Orleans and Washington
Chapter:
Molecular Mechanisms Guiding B-Cell Development: Territorial Administration under Attack in Orleans and Washington
Author(s):

Antonius G. Rolink

and Roxane Tussiwand

DOI:
10.1093/med/9780195389838.003.0005
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date: 18 November 2019

Primary immunodeficiency diseases are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This chapter focuses on Molecular Mechanisms guiding B cell development , including the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings. Where appropriate, diagnostic tools and therapeutic options are outlined -- from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy.

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