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Immune-Mediated Diseases 

Immune-Mediated Diseases
Immune-Mediated Diseases

Robert W. Baloh

, Vicente Honrubia

, and Kevin A. Kerber

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date: 23 April 2021

The immune system is implicated in many neurologic diseases. There are some primary immune-based neurologic diseases, such as multiple sclerosis and myasthenia gravis, and also many secondary immune-based diseases, including paraneoplastic syndromes. In primary immune-mediated diseases the cause is typically not known, but genetic and environmental factors undoubtedly play a role. On the other hand, in secondary immune-based diseases a known inciting event occurs, typically an infection, cancer, or environmental stimulus, in the setting of genetic susceptibility. Immune-mediated disorders are important to identify because in many cases effective therapies are available. In the absence of adequate therapeutic trials, identifying an immune response can at least direct therapeutic approaches for what can otherwise be severely disabling deficits.

In this chapter, we focus on the immune-mediated syndromes that can involve the peripheral audio-vestibular system and also the central vestibular system.

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