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Leslie L. Iversen

, Susan D. Iversen

, Floyd E. Bloom

, and Robert H. Roth

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date: 06 August 2021

Chapter 8 discusses one of the more striking examples of an intensively studied brain biogenic amine, and there is every reason to believe that it is an important synaptic transmitter. Still to be determined are the precise synaptic connections at which this substance transmits information and the functional role these connections play in the overall operation of the brain with respect to both effective and other multicellular interneuronal operations. The central pharmacology of serotonin, however, remains poorly resolved. Specific inhibition of uptake and synthesis are possible, but truly effective and selective postsynaptic antagonists remain to be developed.

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