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Other Interneuronal Signals 

Other Interneuronal Signals
Other Interneuronal Signals

Leslie L. Iversen

, Susan D. Iversen

, Floyd E. Bloom

, and Robert H. Roth

Page of

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date: 24 January 2022

The previous chapters were devoted to what we might now consider the “classical” or perhaps “conventional” neurotransmitters. By this, we mean those transmitters that are synthesized within the neuron (cell body or synaptic terminal) that releases them by activity-dependent, Ca2+-dependent mechanisms to act on discrete receptors largely, but not exclusively, on the neuron, smooth muscle, or gland cell opposite the nerve terminal. However, as the wheels of progress have turned, it seems that once again the more we learn about inter cellular communication in the nervous system, the more complicated the situation becomes. The purine signals discussed in Chapter 11 provided an appetizer by acting both pre- and postsynaptically, as do many of the other classical transmitters. Nevertheless, through improved methods of substance identification and detection of signal responsiveness, several potent interneuronal signals have been recognized that are not stored in vesicles, or even stored at all, but rather seem to be synthesized and released on demand to act more broadly than the immediate-releasing neuron terminals and to modify the effectiveness of the conventional interneuronal signals.

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