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Purinergic Pharmacology 

Purinergic Pharmacology
Chapter:
Purinergic Pharmacology
Author(s):

Leslie L. Iversen

, Susan D. Iversen

, Floyd E. Bloom

, and Robert H. Roth

DOI:
10.1093/med/9780195380538.003.0333
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date: 30 May 2020

Chapter 11 discusses purine base adenine, which is one of the four bases that make up nucleic acids, but its ribonucleoside form, adenosine, and its three nucleotide mono-, di-, and tri-phosphorylated forms (AMP, ADP, and ATP) have probably been much more intensively studied in the energy metabolism of nonneural cells. Subsequent research on the purinergic systems of the central nervous system has established two main categories of signal transduction: sites where adenosine is the mediator (A receptors; Table 11–1) and sites where ATP (and sometimes UTP) is the mediator, often in conjunction with either a monoamine or a neuropeptide. Subsequent work on the receptors for adenosine as a special kind of intercellular signal, a neuromodulator, but not a classic neurotransmitter, and for ATP as a cotransmitter more firmly established their different physiological roles and the pharmacological roles each system has been found to play in the brain as well as the autonomic nervous system.

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