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Leslie L. Iversen

, Susan D. Iversen

, Floyd E. Bloom

, and Robert H. Roth

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date: 24 January 2022

Rsearch on neuropeptides has been an active area for more than 30 years, and scientists continue to view this as an area of great future promise. More than 100 small peptides, ranging from 2 to more than 40 residues long, are synthesized and released from neurons in the central and peripheral nervous system. They act potently on specific receptors, often with more than one receptor subtype for each peptide, adding further to the complexity of neuropeptide signaling. The quantities of peptides involved are minute, and the concentrations needed to activate the receptors are commonly subnanomolar.

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