Genomics and Health in the Developing World

Genomics and Health in the Developing World

Edited by Dhavendra Kumar

Abstract

Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation - with particular emphasis on medical and health issues - in the emerging economies and countries of the developing world. With sections dedicated to fundamentals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this resource highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address inherited disorders in the developing world, the progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide, the ethical and legal concerns of medical genetics in the developing world, and social, cultural, and religious issues related to genetic diseases across continents.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: May 2012

Print ISBN-13:: 9780195374759

Published online:: Feb 2014

DOI:: 10.1093/med/9780195374759.001.0001

Author

Dhavendra Kumar, editor Institute of Medical Genetics, University Hospital of Wales, Cardiff University

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Front Matter
PART I. Genomics in Medicine and Health—General
- 1. Genes and Genomes in Health and Disease: An IntroductionDhavendra Kumar
- 2. The Human Variome Project and the Developing WorldRichard G.H. Cotton
- 3. Human Genomic Variation Initiatives in Emerging Economies and Developing CountriesBéatrice Séguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar
- 4. The Genomic Map of Population Diversity in AsiaDhavendra Kumar
- 5. Ancestry, Disease and Variable Drug Response in the Genomic EraCharles Rotimi and Lynn Jorde
- 6. The Next Steps for Genomic Medicine: Challenges and Opportunities for the Developing WorldBillie-Jo Hardy, Béatrice Séguin, Federico Goodsaid, Gerardo Jiménez-Sánchez, Peter A. Singer, and Abdallah S. Daar
- 7. Consumer Perspectives on Genomics and HealthcareAlastair Kent
- 8. Transcultural Perspectives on Genetics and GenomicsDhavendra Kumar
- 9. Medical Genetics and Genomics Research in the Muslim WorldAida I. Al-Aqeel
- 10. The Progress of Genomics in the Developing World: Rising Social, Economic, and Ethical ConcernsMinakshi Bhardwaj
- 11. Genetic Outcomes of Consanguineous MarriagesAlan H. Bittles and Michael L. Black
- 12. Autosomal Recessive Conditions and Autozygosity MappingColin A. Johnson and Eamonn R. Maher
- 13. Genetic Contribution to Malaria Susceptibility and ResistanceSusana G. Campino and Taane G. Clark
- 14. Glucose 6-Phosphate Dehydrogenase Deficiency: Genetics, Pharmacogenetics, and Malaria SelectionLucio Luzzatto
- 15. Infections, Genomics and Global Public HealthTikki Pang
- 16. Microbial Genomics and Global HealthRino Rappuoli
- 17. Pharmacogenetics and Pharmacogenomics in the Developing WorldWarren E. Hochfeld, Sahle M. Asfaha, Marco Alessandrini, Tyren M. Dodgen, Renier Myburgh, Arinda Eloff, and Michael S. Pepper
- 18. Nutrigenomics Research in World PopulationsJim Kaput
- 19. Transgenic Foods and Nutritional Health in Developing CountriesDhavendra Kumar and Joel Cohen
- 20. The Burden of Genetic Disease in the Developing World: The Example of Inherited Blood DiseasesDavid J. Weatherall
- 21. Health Implications of Inherited Disorders of Iron OverloadChun Yu Lok, Alison T. Merryweather-Clarke, and Kathryn J.H. Robson
- 22. Inherited Factors in Diabetes Mellitus and Related Metabolic Disorders in the Developing WorldDwaipayan Bharadwaj, Nikhil Tandon, and Anubha Mahajan
- 23. Global Health Implications of Genetic Studies of Obesity and Type 2 DiabetesJessica Buxton, Julia El-Sayed Moustafa, Haya Al-Saud, and Alexandra Blakemore
- 24. Health Implications of Familial HyperlipidemiaDeepak Bhatnagar
- 25. Global Health Implications of Inherited Renal DiseasesWendy Jones and Anand Saggar
- 26. The Burden of Congenital Anomalies on Global HealthDhavendra Kumar
- 27. Inherited Eye Diseases in Developing CountriesTiziana Cogliati, James Friedman, Norimoto Gotoh, Neeraj Agarwal, and Anand Swaroop
- 28. Principles and Practice of Newborn Screening: The Lessons from the Developed WorldRodney J. Pollitt
- 29. Diagnostic Genetic Laboratory Services: Models for the Developing WorldPeter Lunt
- 30. Ethical Issues Arising in Medical Genetics in Developing CountriesAngus Clarke
- 31. Genetic and Genomic Services in Emerging Economies of the Developing WorldRobert George Elles
PART II. Genomics in Medicine and Health—Regional
- Africa
  - 32. Anthropology and Population Heterogeneity in North AfricaRym Kefi
  - 33. The Genetic Landscape of Sub-Saharan African PopulationsHimla Soodyall and Carina M. Schlebusch
  - 34. Genetic Disorders in North African PopulationsLilia Romdhane and Sonia Abdelhak
  - 35. Genetic Neurological Diseases in TunisiaNeziha Gouider-Khouja and Ibtihel Rebai
  - 36. Hemoglobinopathies in AfricaAmbroise Wonkam and Amanda Krause
  - 37. The Burden of Birth Defects and Genetic Disease in Sub-Saharan AfricaAmbroise Wonkam
  - 38. Genetic Epidemiology of South Atlantic Oceanic IslandsPeter Beighton
  - 39. Genetic Disorders in Minority Groups in South AfricaPeter Beighton
  - 40. Hereditary Deafness in Southern AfricaPeter Beighton and Sean Sellars
  - 41. Heritable Disorders of the Skeleton in South AfricaPeter Beighton
  - 42. Heritable Disorders of Connective Tissue in South AfricaPeter Beighton
  - 43. Genetic Perspectives of Tuberculosis in Southern AfricaErika de Wit, Marlo Möller, and Eileen Hoal
  - 44. Familial Cancer Syndromes in AfricaYonglan Zheng, Toshio F. Yoshimatsu, and Olufunmilayo I. Olopade
  - 45. Genetic Counseling in South AfricaJacquie Greenberg, Jennifer Kromberg, Kelly Loggenberg, and Tina-Marié Wessels
  - 46. Prenatal Diagnostic Services and Prevention of Birth Defects in South AfricaMichael Urban and Lut Geerts
  - 47. Sociocultural Perspectives of Inherited Diseases in Southern AfricaClaire Penn and Jennifer Watermeyer
  - 48. Ethical, Legal, and Sociocultural Issues and Genetic Services in Southern AfricaJennifer G. R. Kromberg and Trefor Jenkins
  - 49. The Genomic Research and Health Applications in South Africa^,Billie-Jo Hardy, Béatrice Séguin, Raj Ramesar, and Abdallah S. Daar
- Arab and Middle East
  - 50. Hereditary Disorders in ArabsGhazi Omar Tadmouri and Mahmoud Taleb Al Ali
  - 51. Community Health Implications of Consanguinity in Arab PopulationsGhazi Omar Tadmouri, Pratibha Nair, Tasneem Obeid, and Hanan Hamamy
  - 52. Clinical Dysmorphology in the Arab WorldLihadh Al-Gazali and Hanan Hamamy
  - 53. The Population Genetics and Hereditary Diseases of BahrainShaikha Salim Al-Arrayed
  - 54. Genetic Diseases in the Sultanate of OmanAnna Rajab and Michael A. Patton
  - 55. Genetic Disorders in Lebanon: Challenges and OpportunitiesIssam Khneisser, Salim M. Adib, and Andre Megarbane
  - 56. Genetic Disease in Palestine and PalestiniansBassam Abu-Libdeh, Peter D. Turnpenny, and Ahmed Teebi*
  - 57. Genetic Skin Diseases in the Arab WorldMourad Mokni, Cherine Charfeddine, and Sonia Abdelhak
  - 58. Hereditary Diseases of the Nervous System in ArabsNisrine Bissar-Tadmouri, Mohamad Al Homssi, and Pratiba Nair
  - 59. Preimplantation Genetic Diagnosis in Saudi ArabiaSerdar Coskun, Wafa Qubbaj, and Aida I. Al-Aqeel
- Asia-Pacific
  - 60. Genomics for Universal Healthcare in Thailand^,Béatrice Séguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar
  - 61. Screening Newborns in the Asia-Pacific RegionCarmencita D. Padilla and Bradford L. Therrell
  - 62. Clinical Dysmorphology and Birth Defects Registry in the Asia-Pacific RegionMeow Keong Thong
  - 63. Prevention and Control of Thalassemia in ThailandChanane Wanapirak, Jintana Pattanapongthorn, Pranee Winichagoon, and Suthat Fucharoen
  - 64. Inherited Metabolic Disorders in Thailand and the Asia-PacificPornswan Wasant
  - 65. Genetic Skeletal Dysplasias in ThailandPornswan Wasant
  - 66. Medical Genetics Services in the PhilippinesCarmencita Padilla, Eva Maria Cutiongco-de la Paz, and Catherine Lynn Silao
- Chinese Subcontinent
  - 67. Community and Public Health Genetics in ChinaManshu Song, Youxin Wang, Lijuan Wu, Yun Wang, and Wei Wang
  - 68. Genetic Epidemiology in ChinaPeng-Gao Li, Yan He, and Wei Wang
  - 69. Traditional Chinese Medicine in the Area of GenomicsHong-Min Yun, Manshu Song, and Wei Wang
  - 70. Inherited Factors in Cardiovascular Disease in ChinaLing Zhang, Ying Dai, and Wei Wang
  - 71. Familial and Genetic Cancer in ChinaFen Liu and Wei Wang
  - 72. Genomic Medicine in Taiwan: Research and DevelopmentsMing Ta Michael Lee, Chien-Hsiun Chen, and Yuan-Tsong Chen
- Indian Subcontinent
  - 73. The Indian Subcontinent and its PeopleDhavendra Kumar
  - 74. Genomic Perspectives of Peopling and Languages of the Indian SubcontinentGanesh Prasad Arunkumar, Varatharajan Santhakumari Arun, Adhikarla Syama, Valampuri John Mary Selvam Kavitha, and Ramasamy Pitchappan
  - 75. Genomic Diversity of HLA in the Indian SubcontinentNarinder K. Mehra and Gurvinder Kaur
  - 76. Genomic Applications in Medicine and Health in IndiaBillie-Jo Hardy, Béatrice Séguin, Peter A. Singer, Mitali Mukerji, Samir K. Brahmachari, and Abdallah S. Daar,
  - 77. Epidemiology of Genetic Diseases in the Indian SubcontinentIshwar C. Verma and Dhavendra Kumar
  - 78. Genetic Services in India: A Model for Developing CountriesRatna D. Puri and Ishwar C. Verma
  - 79. The Practice of Genetic Counseling in IndiaMeenakshi Bhat
  - 80. Social and Cultural Aspects of Customary Consanguineous Marriages in South AsiaRafat Hussain
  - 81. Medical Genetics and Genomics in Sri LankaVajira H.W. Dissanayake
  - 82. Inherited Factors in Obstructive Lung Diseases in IndiaAmrendra Kumar Gupta, Balaram Ghosh, and Anurag Agrawal
  - 83. Inherited Metabolic Disease in IndiaBal N. Apte
  - 84. Genetic Variation and Genetic Epidemiology of Sri LankaDeepthi C. de Silva
  - 85. Familial Cancer and Cancer Genetics in the Indian SubcontinentDhavendra Kumar
  - 86. Inherited Disorders of the Eye in the Indian SubcontinentGovindasamy Kumaramanickavel
  - 87. Type 2 Diabetes Mellitus in IndiaRadha Venkatesan, Kanthimathi Sekar, and Viswanathan Mohan
  - 88. Hereditary Spinocerebellar Ataxias in IndiaMohammed Faruq, Uma Mittal, Achal K. Srivastava, and Mitali Mukerji
  - 89. Malformation Syndromes in IndiaShubha R. Phadke
  - 90. Thalassemias and Abnormal Hemoglobins of the Indian SubcontinentJohn Old
  - 91. The Management of Inherited Blood Diseases in the Indian SubcontinentReena Das
  - 92. Conventional and Molecular Cytogenetics in IndiaProchi F. Madon
  - 93. Genetic Studies of Parkinson's Disease in IndiaJharna Ray
  - 94. The Genetic Basis of Alcoholism in IndiaMeera Vasani
  - 95. The Genetics of Autism in IndiaG.K. Chetan, K.R. Manjunatha, Sam Balu, H.N. Venkatesh, and S.C. Grimaji
  - 96. The Genetics of Leprosy in IndiaMariakuttikan Jayalakshmi, Narayanan Kalyanaraman, and Ramasamy Pitchappan,
  - 97. The Current Status of Medical Genetics in IndiaNeerja Gupta and Madhulika Kabra
  - 98. The Indian Landscape of Human/Medical Genetics Research and ServiceSwati Naik, Arvind Rup Singh, and Jai Rup Singh
- Latin America and the Caribbean
  - 99. Design and Implementation of a Platform for Genomic Medicine in MexicoGerardo Jiménez-Sánchez, Julio Frenk, and Guillermo Soberón
  - 100. Anthropological and Medical Implications of Genetic Admixture in the Mexican Mestizo PopulationRicardo M. Cerda-Flores and Augusto Rojas-Martínez
  - 101. Medical and Human Genetics in EcuadorCésar Paz-y-Miño
  - 102. The Brazilian AncestromeSérgio D.J. Pena
  - 103. The Practice of Medical Genetics in BrazilDafne Dain Gandelman Horovitz, Antonia Paula Marques-de-Faria, and Victor Evangelista de Faria Ferraz,
  - 104. Population Medical Genetics in BrazilLavinia Schuler-Faccini and Roberto Giugliani
  - 105. Medical Genetic Services in Latin America: Focus in ArgentinaVictor B. Penchaszadeh
  - 106. Hereditary Ataxias in CubaLuis Velázquez-Pérez, José Miguel Laffita-Mesa, and Roberto Rodríguez-Labrada
  - 107. Latin American School of Human and Medical Genetics and Latin American Network of Human Genetics: Promoting Education, Interaction and Networking Across Latin AmericaRoberto Giugliani, Guilherme Baldo and Ursula Matte,
- Russia, Central Asia, and Europe
  - 108. Genetic Legacy of Populations in EurasiaI.A. Kutuev, B.B. Yunusbayev, and Elza K. Khusnutdinova
  - 109. MTDNA and Y-Chromosomal Variation in Populations of Sakha (Yakutia)Sardana A. Fedorova, Elza K. Khusnutdinova, and Richard Villems
  - 110. Epidemiology of Hereditary Diseases in the European Sector of RussiaE.K. Ginter and R.A. Zinchenko
  - 111. Hereditary Diseases Among the YakutsNadezda R. Maksimova and Anna N. Nogovitsina
  - 112. Hereditary Diseases in Siberian PopulationsLudmila P. Nazarenko and V.P. Puzyrev
  - 113. Hereditary Diseases in the Volga-Ural Region of RussiaIrina M. Khidiyatova Irina R. GilyazovaVita L. Akhmetova and Elza K. Khusnutdinova
  - 114. Inherited Neuropsychiatric Disorders in RussiaD. Gaysina A. Zainullina and Elza K. Khusnutdinova
  - 115. Genetics and Genomics Perspectives of Medical and Health Education in HungaryBéla Melegh
  - 116. Human and Medical Genetics in HungaryBéla Melegh
  - 117. The Genetics of Alcohol Dependence in RussiaA. Kazantseva G. Faskhutdinova and Elza K. Khusnutdinova
  - 118. Medical Genetics Teaching and Training in RussiaS.I. Kozlova and E.K. Ginter
  - 119. Ethical and Legal Aspects of Medical Genetics in RussiaV.L. Izhevskaya and V.I. Ivanov
  - 120. Bioethical Aspects of Genetics and Genomics in Yakut (Siberia)S.K. KononovaS.A. Fedorova and Elza K. Khusnutdinova
  - 121. Inherited Metabolic Diseases among Migrant Ethnic Populations in the United KingdomAnupam Chakrapani and Maureen Cleary
  - 122. Views of Inherited Illness among British Pakistani Users of Genetic ServicesAlison Shaw and Jane Hurst
  - 123. Social, Cultural and Religious Issues Related to Genetic Diseases among the Bangladeshis in the UKSanti Rozario and Sophie Gilliat-Ray
End Matter
- Glossary: Selected Terms and Phrases
- Index

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Genomics and Health in the Developing World

Edited by Dhavendra Kumar

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