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Developmental Neurobiology of Autism Spectrum Disorders 

Developmental Neurobiology of Autism Spectrum Disorders
Developmental Neurobiology of Autism Spectrum Disorders

John L. R. Rubenstein

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date: 09 July 2020

Autism spectrum disorders (ASD) are extremely heterogeneous. While genetic etiologies are unquestionably involved, one cannot ignore epigenetic and environmental mechanisms, although the magnitude of their roles is uncertain. Since ASD have their onset in early childhood, all etiologies must interfere with brain development. This chapter addresses some of the neurodevelopmental mechanisms whose derailment may lead to ASD. It first briefly reviews the neuroanatomical and genetic features of ASD in order to provide a context for the developmental models discussed in the chapter.

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