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Optimal Approaches to Diffusion MRI Acquisition 

Optimal Approaches to Diffusion MRI Acquisition
Optimal Approaches to Diffusion MRI Acquisition

Derek K. Jones

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date: 28 January 2020

This chapter focuses on optimizing the acquisition of diffusion MRI data acquisitions. It outlines the theory of optimization and highlights the interplay between different parameters in the pulse sequence (b-value, echo time, choice of sampling directions). Prescriptions are given for designing an optimal protocol suited to a particular laboratory together with practical considerations for implementing such protocols. It addresses questions such as: How many measurements should I take at each b-value?, What is the optimal b-value?, and Which sampling orientations are “best”? The main focus is on diffusion tensor MRI but details for HARDI (high angular resolution diffusion imaging) style acquisitions are also given.

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