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Human Leptin and Leptin Receptor Deficiency 

Human Leptin and Leptin Receptor Deficiency
Human Leptin and Leptin Receptor Deficiency

I. Sadaf Farooqi

and Stephen O'Rahilly

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date: 21 April 2021

Several monogenic forms of human obesity have now been identified by searching for mutations homologous to those causing obesity in mice. Although such monogenic obesity syndromes are rare, the characterization of these disorders has provided insights into the role of leptin in human physiology. Importantly, administration of recombinant human leptin in leptin deficiency represents the first rational, mechanistically based therapy for obesity and has the potential to provide immense clinical benefits for the patients concerned.

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