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Pituitary Diseases 

Pituitary Diseases
Chapter:
Pituitary Diseases
Author(s):

Kevin B. Hoover

DOI:
10.1093/med/9780190938178.003.0080
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date: 28 January 2022

Chapter 80 discusses pituitary diseases. Acromegaly and Cushing disease are the 2 pituitary diseases with the most significant effects on the musculoskeletal system. Acromegaly results in excess growth hormone with gradual bone and soft tissue overgrowth in adults. Cushing disease results in hypercortisolism resulting in osteoporosis, osteonecrosis, and myopathy. Osteoporosis and osteonecrosis are common sequelae of Cushing disease that can often be detected radiographically, but DXA and MRI are often used for confirmation and treatment planning. Both conditions require a high clinical suspicion to diagnose and are primarily treated surgically. Medical treatment with or without adjunctive radiation therapy is reserved for patients with unsuccessful surgical resection or unresectable disease.

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