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Histiocytoses 

Histiocytoses
Chapter:
Histiocytoses
Author(s):

Kevin B. Hoover

DOI:
10.1093/med/9780190938178.003.0077
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date: 28 January 2022

Chapter 77 discusses histiocytoses, which are uncommon myeloid cell disorders. Langerhans cell histiocytosis (LCH) is the most common, with Erdheim-Chester disease (ECD) being less common. In LCH and ECD, the bones are most commonly involved. The imaging characteristics of the histiocytoses are nonspecific, and biopsy is often required for diagnosis. Radiography is standard for the initial assessment of suspected bone lesions. MRI is used to confirm a solid neoplasm, narrow the differential diagnosis, evaluate for risk of pathologic fracture, and guide biopsy. CT is usually performed in areas with lymphadenopathy. Treatment of skeletal disease is most commonly surgical and limited to symptomatic patients or those at risk for pathologic fracture.

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