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The Brain-Gut-Microbiome Axis Communication 

The Brain-Gut-Microbiome Axis Communication
The Brain-Gut-Microbiome Axis Communication

Claudia Sanmiguel

, and Emeran A. Mayer

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date: 15 April 2021

The chapter on brain-gut-microbiome (BGM) axis communication analyzes the interactions between the gut microbiome, the regulatory processes within the gut (including the enteric nervous system [ENS], enteroendocrine cells [EECs], and immune system), and the central nervous system (CNS) (including the brain, hypothalamic-pituitary axis [HPA], and autonomic nervous system), both in brain development and in health, such as modulation of emotional states and ingestive behaviors, and in disease, such as autism spectrum disorder (ASD), irritable bowel syndrome (IBS), Parkinson’s disease, and obesity. Special emphasis is placed on new developments in our understanding of the role that the gut microbiome plays within the BGM axis.

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