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The Gut Microbiome in Integrative Gastroenterology 

The Gut Microbiome in Integrative Gastroenterology
Chapter:
The Gut Microbiome in Integrative Gastroenterology
Author(s):

Gerard E. Mullin

DOI:
10.1093/med/9780190933043.003.0003
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date: 24 June 2021

The gut microbiome consists of trillions of bacteria that play an essential role in human metabolism. Environmental factors play a role in the development of the gut microbiome. Hygiene, antibiotic usage, urbanization, mode of birth, breast-feeding, and family size influence the development of the gut microbiota in early life. Distortion in the gut microbial ecology has been linked to the pathophysiology of many diseases via disruption of the gut barrier lining, promoting local and systemic inflammation, and by the systemic dissemination of bacteria-derived byproducts, and other luminal antigens that set into motion a cascade of deleterious events. Manipulation of the gut flora through diet, prebiotics and probiotics, antibiotics, and fecal transplantation has the potential to influence digestive disease health outcomes.

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