- Dedication
- Contributors
- 1 Sleep Medicine and Psychiatry
- 2 Sleep Architecture and Physiology
- 3 Neurobiology of Sleep and Wakefulness
- 4 Circadian Rhythms
- 5 Sleep and Cognition
- 6 Office-Based Evaluation of Sleep Disordered Patients
- 7 Clinical Applications of Technical Procedures in Sleep Medicine
- 8 Insomnia Disorder—Pathophysiology
- 9 Pharmacological Management of Insomnia
- 10 Insomnia—Behavioral Treatments
- 11 Hypersomnolence Disorders
- 12 Parasomnias
- 13 Circadian Rhythm Sleep Disorders
- 14 Sleep-Related Movement Disorders
- 15 Breathing-Related Sleep Disorders
- 16 Pediatric Sleep–Wake Disorders
- 17 Depressive Disorders
- 18 Bipolar and Related Disorders
- 19 Anxiety, Obsessive-Compulsive, and Related Disorders
- 20 Trauma- and Stressor-Related Disorders
- 21 Schizophrenia Spectrum and Other Psychotic Disorders
- 22 Substance Use Disorders
- 23 Neurodevelopmental Disorders
- 24 Delirium
- 25 Neurocognitive Disorders
- 26 Neurological Disorders
- 27 Pain Disorders
- 28 Psychotropic Medications and Sleep
- 29 Forensic Sleep Medicine
- 30 Eating Disorders
- 31 Future of Sleep Medicine and Psychiatry
- Index
(p. 103) Pharmacological Management of Insomnia
- Chapter:
- (p. 103) Pharmacological Management of Insomnia
- Author(s):
Karl Doghramji
- DOI:
- 10.1093/med/9780190929671.003.0009
Insomnia has posed a management challenge for patients and clinicians for centuries. Historically, a variety of compounds have been utilized for the treatment of this common malady, with many of them associated with unwanted side effects. Over the past few decades, however, a variety of agents have emerged for treatment of insomnia with improved safety profiles. This chapter reviews these agents, with attention to their pharmacokinetic profile, mechanism of action, and other, clinically relevant characteristics. It also discusses a rational approach in the selection of each agent to optimize the treatment of insomnia. The chapter closes with a look toward the future of the pharmacological management of insomnia.
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- Dedication
- Contributors
- 1 Sleep Medicine and Psychiatry
- 2 Sleep Architecture and Physiology
- 3 Neurobiology of Sleep and Wakefulness
- 4 Circadian Rhythms
- 5 Sleep and Cognition
- 6 Office-Based Evaluation of Sleep Disordered Patients
- 7 Clinical Applications of Technical Procedures in Sleep Medicine
- 8 Insomnia Disorder—Pathophysiology
- 9 Pharmacological Management of Insomnia
- 10 Insomnia—Behavioral Treatments
- 11 Hypersomnolence Disorders
- 12 Parasomnias
- 13 Circadian Rhythm Sleep Disorders
- 14 Sleep-Related Movement Disorders
- 15 Breathing-Related Sleep Disorders
- 16 Pediatric Sleep–Wake Disorders
- 17 Depressive Disorders
- 18 Bipolar and Related Disorders
- 19 Anxiety, Obsessive-Compulsive, and Related Disorders
- 20 Trauma- and Stressor-Related Disorders
- 21 Schizophrenia Spectrum and Other Psychotic Disorders
- 22 Substance Use Disorders
- 23 Neurodevelopmental Disorders
- 24 Delirium
- 25 Neurocognitive Disorders
- 26 Neurological Disorders
- 27 Pain Disorders
- 28 Psychotropic Medications and Sleep
- 29 Forensic Sleep Medicine
- 30 Eating Disorders
- 31 Future of Sleep Medicine and Psychiatry
- Index