Show Summary Details
Page of

General Medical Conditions: Comorbidities and Differential Diagnosis 

General Medical Conditions: Comorbidities and Differential Diagnosis
General Medical Conditions: Comorbidities and Differential Diagnosis

Patricia Pilkinton

, and Lori L. Davis

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 21 May 2022

The differential diagnosis of major depressive disorder should include a comprehensive evaluation of past and current medical disorders. Comorbid medical conditions and/or their treatments can be a root cause or a contributor to the depressive episode. Conversely, symptoms of depression can exacerbate or mimic a medical condition. This chapter reviews cardiovascular, pulmonary, endocrine, gastrointestinal, hepatic, immunologic, dermatologic, and neurologic medical conditions that can mimic or exacerbate depression, as well as cancer and pain. Suggestions for treatment and management of depression are provided for each major organ system, as well as medications that have possible depression as a side effect. Untreated depression in patients with general medical conditions is a modifiable risk factor for poor medical outcomes.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.