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Turn the Next Page: Envisioning the Future of Addiction Therapeutics 

Turn the Next Page: Envisioning the Future of Addiction Therapeutics
Turn the Next Page: Envisioning the Future of Addiction Therapeutics

Kathryn A. Cunningham

, Amanda E. Price

, F. Gerard Moeller

, and Noelle C. Anastasio

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date: 28 January 2022

Contemporary research has enriched our knowledge of mechanisms involved in the generation and persistence of the debilitating disorders characterized by an “addictive dimensionality,” such as substance use disorders and binge eating disorder. Personalized treatment strategies for addictive disorders might include one or a combination of medications at important stages in detoxification and recovery to reduce craving, assist in establishing a substance-free state, and open the optimal window to allow cognitive restructuring and enhanced inhibitory control of substance-seeking. The overlapping neural systems and brain circuitry involved across addictive disorders have elevated interest in the metabolic and neural regulators serotonin (5-hydroxytryptamine; 5-HT) and ghrelin. This chapter focuses on these systems as examples of how we can broaden our horizons for advancing future therapeutic and biomarker initiatives.

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