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Evidence-Based Pharmacotherapy for Cocaine, Amphetamine, and Methamphetamine Use Disorders: Overview and History of Clinical Trials 

Evidence-Based Pharmacotherapy for Cocaine, Amphetamine, and Methamphetamine Use Disorders: Overview and History of Clinical Trials
Chapter:
Evidence-Based Pharmacotherapy for Cocaine, Amphetamine, and Methamphetamine Use Disorders: Overview and History of Clinical Trials
Author(s):

Xuefeng Zhang

and Thomas R. Kosten

DOI:
10.1093/med/9780190920197.003.0016
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date: 28 June 2022

Cocaine use disorder is one of the important stimulants use disorders worldwide, and amphetamine/methamphetamine misuse is a growing epidemic. There are no pharmacotherapy treatments approved by the US Food and Drug Administration (FDA) available for these illnesses. Numerous treatments based on a variety of strategies from psychotherapy, pharmacotherapy, to neuromodulation have been tested to date. Clinical efficacy of the trialed treatments, including both negative and positive outcomes. are reviewed and discussed in this chapter. In summary, many agents and interventions showed promising therapeutic potential in preclinical and early phase clinical trials but eventually failed in later larger trials. Thus, behavioral interventions and supportive therapy focusing on detoxification, initial recovery, and relapse prevention remain the major therapeutic approach due to lack of targeted treatment. New strategies and models are urgently needed to develop effective treatments for these detrimental disorders.

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