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The HeartWare HVAD Left Ventricular Assist Device 

The HeartWare HVAD Left Ventricular Assist Device
The HeartWare HVAD Left Ventricular Assist Device

Nicholas Hiivala

and Thomas Vassiliades

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date: 08 March 2021

The HeartWareTM HVADTM System is an intrapericardial continuous-flow left-ventricular assist device with a centrifugal pump design capable of providing full cardiac support in patients with end-stage systolic heart failure. The inflow to the pump is inserted into the left ventricular apex and moves blood to the ascending aorta via a 10mm outflow graft and is most frequently implanted via a median sternotomy. The system is controlled by an external microprocessor unit that connects transcutaneously to the pump by way of a thin, flexible driveline and is powered by Li-ion batteries or AC/DC power. The HVAD was first implanted in man in 2006 and was subsequently approved for use in Europe in 2009 (CE Mark trial), for bridge to transplant in the United States in 2012 (ADVANCE trial), destination therapy in the United States in 2017 (ENDURANCE and ENDURANCE Supplemental trials), and implantation via a thoracotomy approach in the United States in 2018 (LATERAL trial).

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