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Comorbidity of Bipolar Disorder and Medical Disorders 

Comorbidity of Bipolar Disorder and Medical Disorders
Comorbidity of Bipolar Disorder and Medical Disorders

Awad Chowdhury

and Benjamin I. Goldstein

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date: 05 May 2021

Much of the excess mortality in bipolar disorder can be attributed to medical comorbidities, particularly cardiometabolic disorders. This observation has been noted for more than a century. The proportion of excess mortality attributable to cardiovascular disease has increased in recent years. In addition to mortality, there are increased cardiovascular risk factors in bipolar disorder across the life span. The prevalence of these comorbidities is thought to be elevated by aberrations in particular biological pathways, including inflammation, oxidative stress, and neurotrophic factors. Medical comorbidities significantly affect the lives of patients with bipolar disorder in the form of decreased treatment response, increased symptom severity, and increased mortality risk. To successfully ameliorate the negative impacts of medical comorbidities on patients with bipolar disorder, an integrated emphasis on cardiometabolic health alongside mental health is warranted, including behavioral, pharmacological, and systems-related approaches.

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