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Case 61: Small Fiber Neuropathy, Patchy, with Elevated Voltage-Gated Potassium Channel Antibodies 

Case 61: Small Fiber Neuropathy, Patchy, with Elevated Voltage-Gated Potassium Channel Antibodies
Chapter:
Case 61: Small Fiber Neuropathy, Patchy, with Elevated Voltage-Gated Potassium Channel Antibodies
Author(s):

Peter Novak

DOI:
10.1093/med/9780190889227.003.0066
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date: 25 November 2020

This patient presents with disabling pain in the feet for several years, chronic fatigue, and a history of Lyme disease. Neuropathy workup revealed autoimmune small fiber neuropathy with patchy distribution, associated with voltage-gated potassium channel antibodies (VGKC) antibodies. VGKCs modulate the nociceptive sensory threshold. Severe hypocapnic hyperventilation in this patient may be related to chronic pain and cerebral hypoperfusion.

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