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Intravenous Thrombolysis in Acute Ischemic Stroke 

Intravenous Thrombolysis in Acute Ischemic Stroke
Intravenous Thrombolysis in Acute Ischemic Stroke

Waldo R. Guerrero

, Edgar A. Samaniego

, and Santiago Ortega

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date: 23 October 2021

The only proven therapy for patients with acute ischemic stroke is early recanalization. The use of intravenous thrombolytic alteplase is the standard of care for patients presenting with ischemic stroke within the first 4.5 hours from symptom onset. This chapter reviews the indications and contraindications to alteplase including the 2015 American Heart Association guidelines and their relevance to clinical practice. Furthermore, emerging research and ongoing trials on expanding the time window for intravenous thrombolysis are discussed.

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