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Mark E. Frisse

, and Karl E. Misulis

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date: 17 April 2021

Formal research efforts are traditionally managed by trained professionals pursuing systematic investigations seeking improvements based on more rigorous data. An abundance of clinical data liberates research from selected academic institutions and invites broader participation by healthcare professionals. Local registries can allow for informal local analysis and advanced data integration and sharing initiatives can support national and even international research collaborations. Successful approaches rely on enforcement of data standards, application of privacy-protecting technologies, and use of ontologies and other data-mapping tools to ensure reliable interpretation of clinical data. Randomized clinical trials may remain the gold standard, but other, less costly data management approaches can provide many insights with scale and rapidity.

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