Charney & Nestler's Neurobiology of Mental Illness

Charney & Nestler's Neurobiology of Mental Illness (5 ed.)

Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum

Previous Edition (4 ed.)

Abstract

In the years following publication of the DSM-5, the field of psychiatry has seen vigorous debate between the DSM’s more traditional, diagnosis-oriented approach and the NIMH’s more biological, dimension-based RDoC approach. Charney & Nestler’s Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and this edition extends beyond its reference function to acknowledge and examine the controversies and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Section I, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect important technical advances in complex genetics, epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. These established and emerging methodologies offer groundbreaking advances in our ability to study the brain and breakthroughs in our therapeutic toolkit. Sections II through VII cover the neurobiology and genetics of major psychiatric disorders: psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. The last section, Section VIII, focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5 and RDoC. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Nov 2017

Print ISBN-13:: 9780190681425

Published online:: Dec 2017

DOI:: 10.1093/med/9780190681425.001.0001

Authors

Dennis S. Charney, editor Icahn School of Medicine at Mount Sinai

Eric J. Nestler, editor Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai

Pamela Sklar, editor Chief of the Division of Psychiatric Genomics; Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai

Joseph D. Buxbaum, editor Professor of Psychiatry, Neurosciance, and Genetics and Genomic Sciences; Director of the Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai

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Front Matter
- Contributors
Section 1 Emerging and Established Technologies
- 1. Genetic Methodologies and ApplicationsShaun M. Purcell
- 2. Network Methods for Elucidating the Complexity of Common Human DiseasesEric E. Schadt
- 3. The Human Brain and its EpigenomesAndrew Chess and Schahram Akbarian
- 4. Methods for In Vivo Gene ManipulationLisa M. Monteggia and Wei Xu
- 5. Application of Stem Cells to Understanding Psychiatric DisordersKristen Brennand
- 6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and ChallengesLief E. Fenno and Karl Deisseroth
- 7. In Vivo Circuit AnalysisRyan Bowman, Hannah Schwennesen, Kafui Dzirasa, and Rainbo Hultman
- 8. Magnetic Resonance MethodologiesPeter A. Bandettini and Hanzhang Lu
- 9. PET Brain Imaging MethodologiesAnsel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson
- 10. Neuromodulation and Psychiatric DisordersWayne K. Goodman and Mark S. George
- 11. The Neurobiology of SleepGiulio Tononi and Chiara Cirelli
Section 2 Psychotic Disorders
- 12. Diagnosis and Epidemiology of Psychotic DisordersEmma Meyer, Julie Walsh-Messinger, and Dolores Malaspina
- 13. Genetics of Schizophrenia and Bipolar DisorderAlexander Charney and Pamela Sklar
- 14. Neuroimaging of Psychotic DisordersStephan Heckers, Neil Woodward, and Dost Öngür
- 15. Animal and Cellular Models of Psychotic DisordersMikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross
- 16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human StudiesJared W. Young, Alan Anticevic, and Deanna M. Barch
- 17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human StudiesSeth G. N. Grant
- 18. Cellular Mechanisms of Psychotic Disorders: Human StudiesSamuel J. Dienel and David A. Lewis
- 19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human StudiesNao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa
- 20. The Neurobiology and Treatment of Bipolar DisorderKatherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis
- 21. Novel Approaches for Treating Psychotic DisordersTiago Reis Marques and Shitij Kapur
- 22. Current Treatments for Psychotic DisordersDeepak K. Sarpal and Anil K. Malhotra
Section 3 Depression
- 23. Diagnosis and Epidemiology of DepressionNicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough
- 24. Genetics of DepressionDouglas F. Levinson and Walter E. Nichols
- 25. Neuroimaging of DepressionMichele A. Bertocci and Mary L. Phillips
- 26. Animal Models of Mood DisordersLyonna F. Alcantara, Eric M. Parise, and Carlos A. Bolaños-Guzmán
- 27. Neurotrophic Mechanisms of Depression: Animal and Human StudiesRonald S. Duman
- 28. Immune Mechanisms of DepressionCaroline Ménard, Madeline L. Pfau, Georgia E. Hodes, and Scott J. Russo
- 29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical EvidenceJill M. Goldstein, L. Holsen, S. Cherkerzian, M. Misra, and R.J. Handra
- 30. New Approaches for Treating DepressionEric J. Nestler
- 31. Current Treatments for DepressionJohn H. Krystal and Dennis S. Charney
Section 4 Anxiety Disorders
- 32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma and Stressor-Related DisordersMurray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne
- 33. Genetics of Anxiety DisordersTakeshi Otowa, Roxann Roberson-Nay, Mandakh Bekhbat, Gretchen N. Neigh, and John M. Hettema
- 34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety DisordersMadeleine S. Goodkind and Amit Etkin
- 35. Animal Models and Assays Probing Anxiety Related Behaviors and Neural CircuitsRamon Tasan and Nicolas Singewald
- 36. What are Fear and Anxiety? Listening to the BrainJoseph LeDoux
- 37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human StudiesAnfei Li and Francis S. Lee
- 38. The Neurobiology of ResilienceAdriana Feder, Sarah R. Horn, Margaret Haglund, Steven M. Southwick, and Dennis S. Charney
- 39. Novel Approaches for Treating Anxiety DisordersDavid A. Sturman, Milissa L. Kaufman, Cara E. Bigony, and Kerry J. Ressler
- 40. Current and Experimental Treatments for Anxiety DisordersAdam J. Guastella, Alice Norton, Gail A. Alvares, and Christine Yun Ju Song
Section 5 Substance Use Disorders
- 41. Epidemiology of Substance use DisordersDenise B. Kandel, Mei-Chen Hu, Pamela C. Griesler, Bradley T. Kerridge, and Bridget F. Grant
- 42. The Genetic Basis of Addictive DisordersDavid Goldman, Zhifeng Zhou, and Colin Hodgkinson
- 43. Animal Models of AddictionChristopherJ. Evans, Brigitte L. Kieffer, David Jentsch, and Rafael J. Maldonado
- 44. Reward Circuitry and Drug AddictionVaughn R. Steele, Vani Pariyadath, Rita Z. Goldstein, and Elliot A. Stein
- 45. Molecular Neuroimaging in Addictive DisordersEdythe D. London and Chelsea L. Robertson
- 46. Cellular and Molecular Mechanisms of AddictionKathryn J. Reissner and Peter W. Kalivas
- 47. Brain Development and the Risk for Substance AbuseMary M. Heitzeg and B.J. Casey
- 48. Novel Approaches for Treating AddictionJane B. Acri and Phil Skolnick
- 49. Current Approved Pharmacotherapies for Substance Use DisordersAlexis S. Hammond and Eric C. Strain
Section 6 Dementia
- 50. Diagnosis and Epidemiology of DementiaWilliam C. Kreisl and Christiane Reitz
- 51. Genetics of DementiaAlan E. Renton and Alison M. Goate
- 52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer’s DiseaseBrian A. Gordon, Stephanie J.b. Vos, and Anne M. Fagan
- 53. Animal models of Alzheimer’s DiseaseDavid Morgan
- 54. Cellular Mechanisms of Dementia: Animal and Human StudiesLi Gan
- 55. Neurobiology of Lewy Body Dementias: Animal and Human StudiesJames E. Galvin and Jose Tomas Bras
- 56. Neurobiology of FTD: Animal and Human StudiesDah-eun Chloe Chung, Jeannette N. Stankowski, and Leonard Petrucelli
- 57. Current Treatments for Alzheimer’s DiseaseMary Sano and Judith Neugroschil
Section 7 Pediatric Psychiatric Disorders
- 58. Diagnosis and Epidemiology of Pediatric Psychiatric DisordersElise B. Robinson, Benjamin M. Neale, and Mark J. Daly
- 59. Genetics of Pediatric Psychiatric DisordersSilvia De Rubeis, M. Pilar Trelles, and Joseph D. Buxbaum
- 60. Neuroimaging in Pediatric Psychiatric DisordersTimothy P.L. Roberts and Luke Bloy
- 61. Animal and Cellular Models of Pediatric Psychiatric DisordersElodie Drapeau, Hala Harony-Nicolas, and Jacqueline N. Crawley
- 62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human StudiesSilvia De Rubeis, Kathryn Roeder, and Bernie Devlin
- 63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human StudiesJesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R. Hof, Joseph D. Buxbaum and Alexander Kolezvon
- 64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human StudiesStephen V. Faraone, Pradeep G. Bhide, and Joseph Biederman
- 65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human StudiesChristopher Pittenger
- 66. Neurobiology of Eating Disorders: Animal and Human StudiesThomas Hildebrandt and Ashley Heywood
- 67. Novel Approaches for Treating Pediatric Psychiatric DisordersSupritha Prasad and Edwin H. Cook, Jr.
- 68. Current Treatments for Pediatric Psychiatric DisordersM. Pilar Trelles, Paige M. Siper, and Dorothy E. Grice
Section 8 Future of Psychiatric Diagnosis: Toward Precision Psychiatry
- 69. DSM-5 Overview and GoalsDarrel A. Regier, Sarah E. Morris, and Susan K. Schultz
- 70. The Present and Future of Psychiatric DiagnosisSteven E. Hyman
- 71. The Nimh Research Domain Criteria Project: Toward Precision Medicine in PsychiatryBruce N. Cuthbert
- 72. Computational Psychiatry and the Bayesian BrainKarl J. Friston and Raymond J. Dolan
End Matter
- Index

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Charney & Nestler's Neurobiology of Mental Illness (5 ed.)

Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum

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Charney & Nestler's Neurobiology of Mental Illness (5 ed.)

Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum

Abstract

Bibliographic Information

Authors

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Contents