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Advances in Intrathecal Drug Delivery: Impact on Orthopedic Practice 

Advances in Intrathecal Drug Delivery: Impact on Orthopedic Practice
Advances in Intrathecal Drug Delivery: Impact on Orthopedic Practice

Jay S. Grider

, Michael E. Harned

, and Vital Nagar

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date: 11 December 2019

Intrathecal drug delivery has become a commonplace means to treat recalcitrant chronic pain of malignant and nonmalignant origins. Although intrathecal drug delivery systems (IDDS) and intrathecal drug delivery (IDD) itself rapidly established themselves in the treatment of malignant pain at the end of life, these therapies are also utilized for treatment of pain of nonmalignant origin. While the only US Food and Drug Administration (FDA)-approved medications for use in the intrathecal space are morphine, baclofen, and ziconotide, this chapter will also address commonly used medications such as clonidine and local anesthetics such as bupivacaine as well. While this chapter serves as general overview of the topic’s long history and rapidly developing literature, a basic understanding of the modality and medications used is important.

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