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Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study 

Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study
Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study

J. Corey Williams

, and Hanna E. Stevens

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date: 18 September 2020

This chapter provides a summary of a landmark study in child and adolescent psychiatry that addresses the treatment of youth with psychotic disorders. Are second generation antipsychotics superior to first generation antipsychotics in the treatment of early-onset schizophrenia spectrum disorders? Starting with that question, it describes the basics of the study, including funding, study locations, who was studied, how many patients, study design, study intervention, follow-up, endpoints including treatment response and adverse events, results, and criticism and limitations. No differences in symptom change were found between groups, but each group had a specific set of adverse events that distinguished it. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

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