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The Long-Term Natural History of Bipolar I Disorder 

The Long-Term Natural History of Bipolar I Disorder
The Long-Term Natural History of Bipolar I Disorder

Zachary Engler

, and Robert Beech

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date: 03 August 2020

This chapter provides a summary of a landmark study on bipolar disorder. What is the natural progression of symptoms in patients with bipolar I disorder? Overall, how long do people with bipolar I disorder spend with depressive, manic, or other affective symptoms versus periods of euthymia, without controlling treatment modality? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

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