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Clozapine for Treatment-Resistant Schizophrenia 

Clozapine for Treatment-Resistant Schizophrenia
Chapter:
Clozapine for Treatment-Resistant Schizophrenia
Author(s):

Chadrick Lane

, and Vinod H. Srihari

DOI:
10.1093/med/9780190625085.003.0040
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date: 25 August 2019

This chapter provides a summary of a landmark study on the pharmacologic management of treatment-resistant schizophrenia. This clinical trial, conducted by Kane and colleagues, asks whether clozapine is an effective option in the care of patients with treatment-resistant schizophrenia who have not responded to past trials of first-generation antipsychotics. To answer this question, the chapter reviews the basics of the study, including funding sources, study location, inclusion and exclusion criteria, number of participants, research design, interventions, follow-up, endpoints, results, criticisms, and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

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