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Mood Stabilizer Monotherapy versus Adjunctive Antidepressant for Bipolar Depression: The STEP-BD Trial 

Mood Stabilizer Monotherapy versus Adjunctive Antidepressant for Bipolar Depression: The STEP-BD Trial
Chapter:
Mood Stabilizer Monotherapy versus Adjunctive Antidepressant for Bipolar Depression: The STEP-BD Trial
Author(s):

João Paulo De Aquino

, and Robert Beech

DOI:
10.1093/med/9780190625085.003.0004
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date: 22 February 2020

This chapter provides a summary of a landmark study on bipolar disorder, which aims to address the following question: In patients with bipolar disorder receiving mood-stabilizing agents, does adjunctive antidepressant therapy reduce the symptoms of bipolar depression without increasing the risk for mania? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints and results, in addition criticisms and limitations. Subsequently, other relevant studies are briefly reviewed and their clinical implications are discussed. Finally, a relevant clinical exemplifies the application of the current evidence behind the clinical question addressed by the study.

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