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Buprenorphine versus Methadone During Pregnancy: The MOTHER Trial 

Buprenorphine versus Methadone During Pregnancy: The MOTHER Trial
Buprenorphine versus Methadone During Pregnancy: The MOTHER Trial

Rachel Wurmser

, and Kirsten Wilkins

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date: 23 October 2019

This chapter provides a summary of a landmark study in women’s mental health. The study addresses the question of whether buprenorphine is an alternative treatment option to methadone for pregnant women with opioid use disorders. The chapter describes the basics of the study, including funding, location, population studied, study design, interventions, results, and limitations. In short, the study demonstrated that neonates born to mothers with opioid dependence taking buprenorphine during pregnancy required less morphine for the treatment of Neonatal Abstinence Syndrome (NAS), shorter periods of treatment for NAS, and shorter hospital stays compared with neonates born to mothers treated with methadone. The chapter briefly reviews other relevant literature and discusses implications. It concludes with a case to help the reader apply the study to clinical practice.

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